Oh ya, @ extreme: hell ya, I drilled pilot holes with the smallest bit I had, then bored out as needed. For most holes id find myself going through 3-5 bits (pending the size of hole needed). Ya she's rally thick, but like hell I was going to work my ass off only to have it crack a year later lol
Oh ya and on every hole drilled, id have the plexi clamped (very hard!!) to a large piece of 1/2" mdf so they really came out clean.